Proposed review-derived manuscript investigating tumor immune-escape mechanisms through single-cell CRISPR perturbation mapping, spatial immunology, and predictive response modeling for immune checkpoint blockade. The study synthesizes evidence from CRISPR screens, single-cell profiling, and computational frameworks to identify multicellular immune resistance networks, including T-cell exhaustion, immune exclusion, antigen presentation failure, and myeloid suppression. Lead author: Sadia Tasneem. Co-authors, methodology, and study findings will be added following manuscript development and research validation. This topic aligns with her biomedical research interests in cancer immunology, precision medicine, immune regulation, and translational oncology.
CITE THIS ARTICLE
(n.d.). Perturbation-Resolved Single-Cell CRISPR Mapping of Tumor Immune-Escape Networks Predicts Durable Response to Immune Checkpoint Blockade. Nature Cancer. https://www.sadiaresearchhub.com/research/10822688-96ed-590c-b215-029912dc7b1e
(n.d.) ‘Perturbation-Resolved Single-Cell CRISPR Mapping of Tumor Immune-Escape Networks Predicts Durable Response to Immune Checkpoint Blockade’. Nature Cancer. Available at: https://www.sadiaresearchhub.com/research/10822688-96ed-590c-b215-029912dc7b1e
“Perturbation-Resolved Single-Cell CRISPR Mapping of Tumor Immune-Escape Networks Predicts Durable Response to Immune Checkpoint Blockade.” Nature Cancer, n.d., https://www.sadiaresearchhub.com/research/10822688-96ed-590c-b215-029912dc7b1e.
“Perturbation-Resolved Single-Cell CRISPR Mapping of Tumor Immune-Escape Networks Predicts Durable Response to Immune Checkpoint Blockade.” Nature Cancer (n.d.). https://www.sadiaresearchhub.com/research/10822688-96ed-590c-b215-029912dc7b1e.
Perturbation-Resolved Single-Cell CRISPR Mapping of Tumor Immune-Escape Networks Predicts Durable Response to Immune Checkpoint Blockade. Nature Cancer. n.d.. https://www.sadiaresearchhub.com/research/10822688-96ed-590c-b215-029912dc7b1e
@article{article_1082268896ed590cb215029912dc7b1e,
title = {Perturbation-Resolved Single-Cell CRISPR Mapping of Tumor Immune-Escape Networks Predicts Durable Response to Immune Checkpoint Blockade},
journal = {Nature Cancer},
url = {https://www.sadiaresearchhub.com/research/10822688-96ed-590c-b215-029912dc7b1e},
}
TY - JOUR
TI - Perturbation-Resolved Single-Cell CRISPR Mapping of Tumor Immune-Escape Networks Predicts Durable Response to Immune Checkpoint Blockade
JO - Nature Cancer
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Proposed MPH thesis–derived manuscript examining occupational health risks, reproductive and menstrual-health needs, hygiene practices, and access to healthcare among female garment workers in Bangladesh. Lead author: Dr. Sadia Tasneem. Co-authors, methodology, and study findings will be added after thesis completion and supervisor approval. This topic aligns with her MPH specialization in Reproductive and Child Health and her occupational-health experience in the garment sector.
Proposed integrative biomedical manuscript examining immune-metabolic stress pathways, beta-cell dysfunction, and recovery potential during early diabetes progression. The study explores mitochondrial stress, inflammatory signaling, oxidative damage, endoplasmic-reticulum dysfunction, single-cell multi-omic profiles, and circulating biomarkers associated with reversible and progressive beta-cell failure. Lead author: Sadia Tasneem. Co-authors, methodology, and study findings will be added after
